Sofosbuvir Pricing

Rapid reductions in prices for generic sofosbuvir and daclatasvir to treat hepatitis C

Andrew Hill, 1 Bryony Simmons, 2 Dzintars Gotham, 2 and Joseph Fortunak 3

Author information ► Copyright and License information ►

Abstract
Objectives:
Novel treatments for hepatitis C demonstrate high cure rates, but current high prices can be a barrier to rapid global treatment scale-up. Generic competition can rapidly lower drug prices. Using data on exports of raw materials in 2015, we calculated currently feasible generic prices of sofosbuvir and daclatasvir.

Methods:
Data on per-kilogram prices of sofosbuvir and daclatasvir active pharmaceutical ingredients (API) exported from India were extracted from an online database. To the cost of the amount of API needed for a 12-week treatment course, we added cost estimates for formulation (40%), packaging (US$0.35/month), and a mark-up (50%).

Results:
Between 1 January and 15 October 2015, over 5 tons of sofosbuvir were exported, with prices decreasing by US$702/kg/month, and observed prices of US$2501/kg in early September. Over the same period, 84 kg of daclatasvir were exported, with prices decreasing by US$1664/kg/month to US$1897/kg. Using the price estimation algorithm, we estimated the price of a generic sofosbuvir–daclatasvir combination regimen at US$200 per patient for a 12-week treatment course.

Conclusion:
The costs of generic production of sofosbuvir and daclatasvir are rapidly decreasing. Sofosbuvir–daclatasvir combination treatment could be produced for US$200 per patient per 12-week course.

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Latin America’s Pharmaceutical Prices: The Perfect Storm is Here

How prepared are pharma for Latin America's pricing storm?

"Perfect Storm" is a popular term to describe a situation in which several seemingly separate events take place at the same time and place, causing an aggregated effect beyond the sum of their individual impact. I cannot find a better term to describe what is happening now in the pricing environment of pharmaceuticals, in Latin America.

for complete article 

http://social.eyeforpharma.com/market-access/latin-americas-pharmaceutical-prices-perfect-storm-here

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South Africa: The Banal Evil of Drug Pricing - allAfrica.com

South Africa: The Banal Evil of Drug Pricing - allAfrica.com

NALYSISBy Nathan Geffen

Martin Shkreli was the most hated man on the internet for a brief time this week. His company, Turing Pharmaceuticals, pushed up the price of a medicine, pyrimethamine, used to treat a life-threatening disease from $13.50 (approx R185) to $750 (approx R10,250) a pill.

Shkreli is dislikeable. Read this, this, this and watch this:

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How to get Authentic Drug Pricing in Different countries (Retail, Ex-Factory, FOB/ CIF Price etc.)

Pharmaceutical pricing 

The use of external reference pricing by Kai Ruggeri, Ellen Nolte.

This document provided detailed information, how Drug pricing is determined in EU Counties. 

The RAND Corporation is a nonprofit institution that helps improve policy and decisionmaking through research and analysis. This electronic document was made available from www.rand.org as a public service of the RAND Corporation.

This report is part of the RAND Corporation research report series. RAND reports present research findings and objective analysis that address the challenges facing the public and private sectors. All RAND reports undergo rigorous peer review to ensure high standards for research quality and objectivity

Pharmaceutical pricing - The use of external reference pricing

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